Dr Graeme Zosky joined the Institute in 2003 and heads the Lung Growth and Respiratory Environmental Health Group. His major research interests are;
1) Early life determinants of lung growth with a focus on structure/function relationships in disease,
2) Environmental health (with a focus on respiratory disease) and,
3) Mechanisms of the lung dysfunction associated with asthma.

Dr Zosky’s research uses a multi-disciplinary approach through national and international collaborations with clinical, cellular, molecular and genetic researchers. Dr Zosky has been instrumental in the development of state of the art techniques for measuring lung function in animal models.

Journal Articles
Zosky, G. R. (2001) A method for measuring the ECG and ventilation rate in bats. Journal of the Royal Society of Western Australia. 84: 119-120.

Zosky, G. R. (2002) The parasympathetic nervous system: its role during torpor in the fat-tailed dunnart (Sminthopsis crassicaudata). Journal of Comparative Physiology. 172B: 677-684. (Impact Factor: 1.897)

Zosky, G. R. and O’Shea, J. E. (2003) The cardiac innervation of a marsupial heterotherm, the fat-tailed dunnart (Sminthopsis crassicaudata). Journal of Comparative Physiology. 173B: 293-300. (Impact factor 1.897)

Zosky, G. R. and Larcombe, A. N. (2003) The parasympathetic nervous system and its influence on heart rate in torpid western pygmy possums (Cercatetus concinnus). Zoology. 106: 143-150. (Impact factor: 1.562)

Zosky, G. R., von Garnier, C., Stumbles, P.A., Holt P.G., Sly, P.D. and Turner, D.J. (2004) The pattern of methacholine responsiveness in mice is dependent on antigen challenge dose. Respiratory Research. 5: 15. (Impact factor: 3.127)

Collins, R.A., Gualano, R.C., Zosky, G.R., Atkins, C.L., Turner, D.J., Colasurdo, G.N., Sly, P.D. (2005) Hyperresponsiveness to inhaled but not intravenous methacholine during acute respiratory syncytial virus in mice. Respiratory Research. 6: 142. (Impact factor: 3.127)

Kendall, M., Mitchell, T.J., Costigan, G., Armitage, M., Lenzo, J.C., Thomas, J.A., von Garnier, C., Zosky, G.R., Turner, D.J., Stumbles, P.A., Sly, P.D., Holt, P.G., Thomas, W.R. (2006) Downregulation of IgE antibody and allergic responses in the lung by epidermal biolistic microparticle delivery. Journal of Allergy and Clincial Immunology 117: 275-282. (Impact factor: 9.165)

Janosi, T.Z., Adamicza, A., Zosky, G.R., Asztalos, T., Sly, P.D., Hantos, Z. (2006) Plethysmographic estimation of thoracic gas volume in apneic mice. Journal of Applied Physiology. 101: 454-459. (Impact factor: 3.732)

Jahnsen, F.L., Strickland, D.H., Thomas, J.A., Tobagus, I.T., Napoli, S., Zosky, G.R., Turner, D.J., Sly, P.D., Stumbles, P.A., Holt, P.G. (2006) Accelerated antigen sampling and transport by airway mucosal dendritic cells following inhalation of a bacterial stimulus. Journal of Immunology. 177: 5861-5867. (Impact factor: 5.646)

Zosky, G.R., Sly, P.D. and Turner, D.J. (2006) Mouse models of asthma: what physiological evidence are they based on? Allergy and Clinical Immunology International. 18: 76-79. (Impact factor 0.615)

Strickland, D.H., Stumbles, P.A., Zosky, G.R., Subrata, L.S., Thomas, J.A., Turner, D.J., Sly, P.D., Holt, P.G. (2006) Reversal of airway hyperresponsiveness by induction of airway mucosal CD4+CD25+ regulatory T cells. Journal of Experimental Medicine. 203: 2649-2660. (Impact factor: 14.505)

Collins, R.A., Gualano, R.C., Zosky, G.R., Chiappetta, C.L., Turner, D.J., Colasurdo, G.N., Hantos, Z., Sly, P.D. (2007) Lack of long-term effects of respiratory syncytial virus infection on airway function in mice. Respiratory Physiology and Neurobiology. 156: 345-352. (Impact factor: 2.135)

McGlade, J.P., Gorman S., Zosky, G.R., Larcombe, A.N., Sly, P.D., Finlay-Jones, J.J., Turner, D.J., Hart, P.H. (2007) Suppression of the asthmatic phenotype by UVB-induced, antigen-specific regulatory cells. Clinical and Experimental Allergy. 37: 1267-1276. (Impact factor: 4.084)

von Garnier, C., Wikstrom, M.E., Zosky G.R., Turner, D.J., Sly, P.D., Smith, M., Thomas, J.A., Judd, S.R., Strickland, D.H., Holt, P.G., Stumbles, P.A. (2007) Allergic airways disease develops after an increase in allergen capture and processing in the airway mucosa. Journal of Immunology. 179: 5748-5749. (Impact factor: 5.646)

Zosky, G.R., Larcombe, A.N., White, O.J., Burchell, J.T., Janosi, T.Z., Hantos, Z., Holt, P.G., Sly, P.D., Turner, D.J. (2007) Ovalbumin sensitised mice are good models for airway hyperresponsiveness but not acute physiological responses to allergen inhalation. Clinical and Experimental Allergy. 38: 829-838. (Impact factor: 4.084)
***This article was accompanied by an editorial from Prof CG Irvin***

Larcombe, A.N., Zosky, G.R., Bozanich, E.M., Turner, D.J., Hantos, Z, Sly, P.D. (2008) Absence of cholinergic airway tone in normal BALB/c mice. Respiratory Physiology and Neurobiology. 161: 223-229. (Impact factor: 2.135)

Cannizzaro, V, Zosky, G.R., Hantos, Z., Turner, D.J., Sly, P.D. (2008) High tidal volume ventilation in infant mice. Respiratory Physiology and Neurobiology. 162: 93-99. (Impact factor: 2.135)

Zosky, G.R., Janosi, T.Z., Adamicza, A., Bozanich, E.M., Cannizzaro, V., Larcombe, A.N., Turner, D.J., Sly, P.D., Hantos, Z. (2008) The bimodal quasi-static and dynamic elastance of the murine lung. Journal of Applied Physiology. 105: 685-692. (Impact factor: 3.732)

Bozanich, E.M., Gualano, R., Zosky, G.R., Larcombe, A.N., Turner, D.J., Hantos, Z., Sly, P.D. (2008) Acute influenza A infection in mice induces bronchial hyperresponsiveness. Respiratory Physiology and Neurobiology. 162: 190-196. (Impact factor: 2.135)

Cannizzaro V., Berry, L.J., Zosky, G.R., Turner, D.J., Hantos, Z., Sly, P.D. (2009) Impact of supplemental oxygen in mechanically ventilated adult and infant mice. Respiratory Physiology and Neurobiology. 165: 61-66. (Impact factor: 2.135)

Zosky G.R., Larcombe, A.N., White, O.J., Burchell, J.T., von Garnier, C., Holt, P.G., Turner, D.J., Wikstrom, M.E., Sly, P.D., Stumbles, P.A. (2009) Airway hyperresponsiveness is associated with activated CD4+ T cells in the airways. American Journal of Physiology – Lung Cellular and Molecular Physiology. 297: L373-L379. (Impact factor: 4.043)

Cannizzaro V., Berry, L.J., Nicholls, P.K., Zosky, G.R., Turner, D.J., Hantos, Z., Sly, P.D. (2009) Lung volume recruitment manoeuvres and respiratory system mechanics in mechanically ventilated mice. Respiratory Physiology & Neurobiology. 169: 243-251. (Impact factor: 2.135)

Zosky, G.R., Cannizzaro, V., Hantos, Z., Sly, P.D. (2009) Protective mechanical ventilation does not exacerbate lung function impairment or lung inflammation following influenza A infection. Journal of Applied Physiology. 107: 1472-1478 (Impact factor: 3.732) ***Listed as recommended reading on the Faculty of 1000 Biology***

McGlade, J.P., Strickland, D.H., Lambert, M.J.M., Gorman, S., Thomas, J.A., Judge, M.A., Burchell, J.T., Zosky, G.R., Hart, P.H. (2010) UV inhibits allergic airways disease in mice by reducing effector CD4+ T cells. Clinical and Experimental Allergy. 40: 772-785. (Impact factor 4.084)

Foong, R.E., Sly, P.D., Larcombe, A.N., Zosky, G.R. (2010) No role for neutrophil elastase in influenza-induced cellular recruitment, cytokine production or airway hyperresponsiveness in mice. Respiratory Physiology and Neurobiology. In press (Impact factor 2.135)

Reviews
Zosky, G.R., Sly, P.D. (2007) Animal models of asthma. Clinical and Experimental Allergy. 37: 973-988. (Impact factor: 3.556) ***Listed as a Journal Highlight ***